|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.
|
21912683 |
2011 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied the association between the Glu298Asp polymorphism of the NO producing gene, endothelial nitric oxide synthase (eNOS), and hypertension, left ventricular mass (LVM) and carotid artery intima-media thickness (IMT) in a population-based cohort of hypertensive and control subjects.
|
11905585 |
2002 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied eNOS polymorphisms in the promoter region (T-786C), in exon 7 (Glu298Asp), and in intron 4 (b/a) in 98 controls, 68 patients with HT, 66 patients with T2DM, and 86 patients with T2DM+HT.
|
17306574 |
2007 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans.
|
19373110 |
2009 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We recently identified a missense variant (Glu298Asp) that lies within exon 7 of the endothelial nitric oxide synthase (eNOS) gene, and that is associated with severe preeclampsia (proteinuric hypertension that develops as a consequence of pregnancy).
|
11354626 |
2001 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension</span> in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the allelic variation (G894T) in the eNOS gene locus in conjunction with insulin resistance may be one factor contributing to the predisposition to hypertension.
|
11710784 |
2001 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggested no association between the Glu298Asp gene polymorphism and the incidence of hypertension in this selected population.
|
15475025 |
2004 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that the Glu298Asp variant may be a genetic susceptibility factor for hypertension.
|
10883733 |
2000 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results do not support the hypothesis that the E298D polymorphism contributes to the genetic susceptibility to hypertension.
|
15942458 |
2005 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no significant interaction between dietary fat intake and NOS3 Glu298Asp genotype with regards to hypertension status in either African Americans or whites (P for interaction=0.3 and 0.4, respectively).
|
19960019 |
2010 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was an increased prevalence of hypertension and increased atria in Glu298Glu patients comparing with combined genotype Glu298Asp and Asp298Asp.
|
20079452 |
2010 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of the present study support that homozygosity for +G894T (E298D) in NOS3 is a genetic risk factor for the development of LVH in patients with hypertension.
|
19132956 |
2009 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relevance of the Glu298Asp polymorphism to hypertension in this population was tested in 2 ways.
|
10205226 |
1999 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship between the G894T polymorphism and hypertension in Han Chinese may be attributed to the difference in geographic background of subjects.
|
24846690 |
2015 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study evidenced that rs1799983 NOS3 polymorphism could be associated with hypertension and DBP among Southern Europeans, being this association influenced by dietary fat (SFA and MUFA) and body mass index.
|
26994605 |
2017 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T(-786)C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents.
|
20661250 |
2011 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The AGT M235T and eNOS G894T polymorphisms are unlikely to play an important role in the pathogenesis of hypertension in Malays.
|
17977523 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu298Asp, T786C and 4a/4b genetic polymorphisms within the endothelial nitric oxide synthase (e-NOS) gene may predispose to hypertension, ischaemic heart disease and renal damage, possibly by reducing the generation of nitric oxide (NO), a fundamental substance in renal and cardiovascular biology.
|
17563560 |
2007 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies on the associations between the nitric oxide synthase gene (NOS3) Glu298Asp polymorphism and hypertension status or blood pressure (BP) levels have had inconsistent results.
|
15505116 |
2004 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers.
|
18550157 |
2008 |
|
rs1799983
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |